|
KMID : 0358419960390020390
|
|
Korean Journal of Obstetrics and Gynecology
1996 Volume.39 No. 2 p.390 ~ p.396
|
|
|
Angiogenesis in Carcinoma of the Uterine Cervix
|
|
|
|
|
Abstract
|
|
|
Angiogenesis, the formation of new vessels, has been associated with tumor growth. Experimental evidence suggests that the neovascularization increases the opportunity for tumor cells to enter the circulation and is correlated with metastasis.
To investigate if angiogenesis is a related factor in carcinoma of the uterine cervix, we counted microvessles and graded the density of microvessels in 30 patients with squamous cell carcinoma of the cervix. Tumor sections were stained
immunohistochemically with factor VIII to identify all vessels. The microvessels were counted and graded in the most intense areas of neovasulcarization by light microscopy. Microvessel counts in patients with squamous cell carcinoma were
significantly
different from those of normal cervix and chronic cervicitis in 200x field microscopy : 22.43±17.31 vs. 6.57±3.26 and 10.93±7.35(p=0.0182). There was no correlation between microvessel count and clinical parameters such as tumor size or
clinical
FIGO
stage.
This study suggests that tumor angiogenesis could be involved in squmous cell carcinoma of the uterine cervix. However, microvessel counts may not be prognostic value in patients having risk factors for poor clinical outcomes.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|